Additional file 1.

Examples of L1 domain organisation. (a) Genome Environment Browser (GEB) histogram plot of mouse chromosome 4 illustrating the frequency of genes (green bars), CpG islands (lilac bars), full length L1 (FL-L1) elements (light blue bars), L1 homology sequences (yellow bars) and short interspersed nuclear elements (SINEs, grey bars) within 1-Mb intervals. The 25 Mb regions highlighted by a red box are shown in GEB detailed view in (b). (b) The 25 Mb region 1 (top panel) with boxed areas illustrating small (left) and moderate (right) sized gene-rich domains that are depleted for FL-L1. Note that gene density (green boxes) is higher in these domains. The 25 Mb region 2 (bottom panel) illustrates a large low L1 density (LL1) domain (approximately 22 Mb) flanked on each side by a small high L1 density (HL1) domain.

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Tang et al. Epigenetics & Chromatin 2010 3:10   doi:10.1186/1756-8935-3-10