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This article is part of the supplement: Epigenetics and Chromatin: Interactions and processes

Open Access Oral presentation

Reprogramming the chromain landscape at eukaryotic regulatory elements

Gordon L Hager

  • Correspondence: Gordon L Hager

Author Affiliations

Lv of Receptor Biology & Gene Expression, NIC/NIH, Bethesda, MD, 20892, USA

Epigenetics & Chromatin 2013, 6(Suppl 1):O20  doi:10.1186/1756-8935-6-S1-O20


The electronic version of this article is the complete one and can be found online at: http://www.epigeneticsandchromatin.com/content/6/S1/O20


Published:18 March 2013

© 2013 Hager; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Oral presentation

Eukaryotic transcription factors (TFs) regulate gene expression by interacting with chromatinized DNA response elements (REs). Access to these elements is dramatically restricted by chromatin organization, and modification of the nucleoprotein structure to allow factor binding is emerging as a key feature of cell selective gene regulation [1-4]. These processes are highly dynamic, often with oscillatory or cyclical components operating on multiple time scales. Furthermore, many regulatory elements are located at great distance from target genes; long range interactions must play a significant, possibly dominant, role in gene regulation [5,6]. We will discuss an integrated dynamic model for regulatory element function on multiple scales.

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